Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology

Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology

5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural AL...

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Bibliographic Details
Main Authors: Liang Lou, Shizhe Zhou, Sijia Tan, Menghua Xiang, Wei Wang, Chuang Yuan, Liqian Gao, Qicai Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
5-aminolevulinic acid
biotransformation
photodynamic therapy
prodrug
nanotechnology
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1137707/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1137707/full

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