Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology
5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural AL...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1137707/full |
| _version_ | 1797894366455398400 |
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| author | Liang Lou Shizhe Zhou Sijia Tan Menghua Xiang Wei Wang Chuang Yuan Chuang Yuan Liqian Gao Qicai Xiao |
| author_facet | Liang Lou Shizhe Zhou Sijia Tan Menghua Xiang Wei Wang Chuang Yuan Chuang Yuan Liqian Gao Qicai Xiao |
| author_sort | Liang Lou |
| collection | DOAJ |
| description | 5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural ALA has disadvantages such as weak lipophilicity, low stability and poor bioavailability, greatly reducing its clinical performance. The emerging nanotechnology is expected to address these limitations and thus improve the therapeutic outcomes. Herein, we summarized important recent advances in the design of ALA-based prodrugs using nanotechnology to improve the efficacy of PDT. The potential limitations and future perspectives of ALA-based nanomedicines are also briefly presented and discussed. |
| first_indexed | 2024-04-10T07:07:51Z |
| format | Article |
| id | doaj.art-eff54de5c2dc491494e8b2f310b0cbb1 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T07:07:51Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-eff54de5c2dc491494e8b2f310b0cbb12023-02-27T05:30:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-02-011410.3389/fphar.2023.11377071137707Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnologyLiang Lou0Shizhe Zhou1Sijia Tan2Menghua Xiang3Wei Wang4Chuang Yuan5Chuang Yuan6Liqian Gao7Qicai Xiao8School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University and Shenzhen Campus of Sun Yat-sen University, Shenzhen, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University and Shenzhen Campus of Sun Yat-sen University, Shenzhen, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University and Shenzhen Campus of Sun Yat-sen University, Shenzhen, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University and Shenzhen Campus of Sun Yat-sen University, Shenzhen, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University and Shenzhen Campus of Sun Yat-sen University, Shenzhen, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University and Shenzhen Campus of Sun Yat-sen University, Shenzhen, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University and Shenzhen Campus of Sun Yat-sen University, Shenzhen, China5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural ALA has disadvantages such as weak lipophilicity, low stability and poor bioavailability, greatly reducing its clinical performance. The emerging nanotechnology is expected to address these limitations and thus improve the therapeutic outcomes. Herein, we summarized important recent advances in the design of ALA-based prodrugs using nanotechnology to improve the efficacy of PDT. The potential limitations and future perspectives of ALA-based nanomedicines are also briefly presented and discussed.https://www.frontiersin.org/articles/10.3389/fphar.2023.1137707/full5-aminolevulinic acidbiotransformationphotodynamic therapyprodrugnanotechnology |
| spellingShingle | Liang Lou Shizhe Zhou Sijia Tan Menghua Xiang Wei Wang Chuang Yuan Chuang Yuan Liqian Gao Qicai Xiao Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology Frontiers in Pharmacology 5-aminolevulinic acid biotransformation photodynamic therapy prodrug nanotechnology |
| title | Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology |
| title_full | Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology |
| title_fullStr | Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology |
| title_full_unstemmed | Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology |
| title_short | Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology |
| title_sort | amplifying the efficacy of ala based prodrugs for photodynamic therapy using nanotechnology |
| topic | 5-aminolevulinic acid biotransformation photodynamic therapy prodrug nanotechnology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1137707/full |
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