Low Frequency of Cancer-Predisposition Gene Mutations in Liver Transplant Candidates with Hepatocellular Carcinoma

Low Frequency of Cancer-Predisposition Gene Mutations in Liver Transplant Candidates with Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) mainly stems from liver cirrhosis and its genetic predisposition is believed to be rare. However, two recent studies describe pathogenic/likely pathogenic germline variants (PV) in cancer-predisposition genes (CPG). As the risk of de novo tumors might be increased in P...

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Bibliographic Details
Main Authors: Klara Horackova, Sona Frankova, Petra Zemankova, Petr Nehasil, Marta Cerna, Magdalena Neroldova, Barbora Otahalova, Jan Kral, Milena Hovhannisyan, Viktor Stranecky, Tomas Zima, Marketa Safarikova, Marta Kalousova, CZECANCA Consortium, Jan Novotny, Jan Sperl, Marianna Borecka, Sandra Jelinkova, Michal Vocka, Marketa Janatova, Petra Kleiblova, Zdenek Kleibl, Milan Jirsa, Jana Soukupova
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
hepatocellular carcinoma
liver cirrhosis
liver transplantation
genetic predisposition
panel sequencing
MRN complex
Online Access:https://www.mdpi.com/2072-6694/15/1/201

Internet

https://www.mdpi.com/2072-6694/15/1/201

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