<i>MLH1</i> Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis

<i>MLH1</i> Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis

(1) Background: <i>MLH1</i> hypermethylation is an epigenetic alteration in the tumorigenesis of colorectal cancer (CRC) and endometrial cancer (EC), causing gene silencing, and, as a consequence, microsatellite instability. Commonly, <i>MLH1</i> hypermethylation is considere...

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Bibliographic Details
Main Authors: Ileana Wanda Carnevali, Giulia Cini, Laura Libera, Nora Sahnane, Sofia Facchi, Alessandra Viel, Fausto Sessa, Maria Grazia Tibiletti
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Genes
Subjects:
Lynch syndrome
<i>MLH1</i> methylation
constitutional epimutation
LS universal screening
Online Access:https://www.mdpi.com/2073-4425/14/11/2060

Internet

https://www.mdpi.com/2073-4425/14/11/2060

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