Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on cells transformed with KRASG12V, and driven by MAPK...

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Bibliographic Details
Main Authors: Alexander J Martinko, Charles Truillet, Olivier Julien, Juan E Diaz, Max A Horlbeck, Gordon Whiteley, Josip Blonder, Jonathan S Weissman, Sourav Bandyopadhyay, Michael J Evans, James A Wells
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
cancer target discovery
antibody engineering
oncogenic RAS
Online Access:https://elifesciences.org/articles/31098

Internet

https://elifesciences.org/articles/31098

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