Amiodarone Induced Fulminant Hepatotoxicity: A Case Report
Amiodarone is an iodine-rich Class III antiarrhythmic drug, which acts via membrane ion channels. It is metabolised in the liver to produce the active metabolite desethylamiodarone. It is highly lipophilic with a large volume of distribution and accumulates in many different tissues, especially the...
| المؤلفون الرئيسيون: | , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
JCDR Research and Publications Private Limited
2018-11-01
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| سلاسل: | Journal of Clinical and Diagnostic Research |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://jcdr.net/articles/PDF/12295/35445_CE[Ra1]_F(RK)_PF1(AJ_SL)_PN(P).pdf |
| الملخص: | Amiodarone is an iodine-rich Class III antiarrhythmic drug, which acts via membrane ion channels. It is metabolised in the liver to produce the active metabolite desethylamiodarone. It is highly lipophilic with a large volume of distribution and accumulates in many different tissues, especially the liver. It is widely used in supraventricular and ventricular arrhythmias and given as a loading dose, either via the intravenous or oral route, followed by maintenance doses. The common adverse effects of amiodarone are nausea, vomiting, tremor, thyroid dysfunction, peripheral neuropathy, photosensitivity, bradyarrhythmia, worsening of arrhythmia and the less common ones are pneumonitis, optic neuropathy and hepatotoxicity. |
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| تدمد: | 2249-782X 0973-709X |