PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL
PRDM14 is an epigenetic regulator known for maintaining embryonic stem cell identity and resetting potency in primordial germ cells. However, hematopoietic expression of Prdm14 at supraphysiological levels results in fully penetrant and rapid-onset T-cell acute lymphoblastic leukemia (T-ALL) in the...
| Үндсэн зохиолчид: | , , , , |
|---|---|
| Формат: | Өгүүллэг |
| Хэл сонгох: | English |
| Хэвлэсэн: |
The Company of Biologists
2016-05-01
|
| Цуврал: | Biology Open |
| Нөхцлүүд: | |
| Онлайн хандалт: | http://bio.biologists.org/content/5/5/645 |