Antitumor Effect of Brusatol in Acute Lymphoblastic Leukemia Models Is Triggered by Reactive Oxygen Species Accumulation

Antitumor Effect of Brusatol in Acute Lymphoblastic Leukemia Models Is Triggered by Reactive Oxygen Species Accumulation

Acute lymphoblastic leukemia (ALL) is one of the most common hematological malignancies at pediatric ages and is characterized by different chromosomal rearrangements and genetic abnormalities involved in the differentiation and proliferation of lymphoid precursor cells. Brusatol is a quassinoid pla...

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Bibliographic Details
Main Authors: Joana Jorge, Nisa Magalhães, Raquel Alves, Beatriz Lapa, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biomedicines
Subjects:
oxidative stress
NRF2 inhibitors
acute lymphoblastic leukemia
reactive oxygen species
mitochondria
Online Access:https://www.mdpi.com/2227-9059/10/9/2207

Internet

https://www.mdpi.com/2227-9059/10/9/2207

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