Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice.

Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice.

BACKGROUND: The four and a half LIM-only protein 2 (FHL2) is capable of shuttling between focal adhesion and nucleus where it signals through direct interaction with a number of proteins including beta-catenin. Although FHL2 activation has been found in various human cancers, evidence of its functio...

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Bibliographic Details
Main Authors: Charlotte Labalette, Yann Nouët, Florence Levillayer, Sabine Colnot, Ju Chen, Valere Claude, Michel Huerre, Christine Perret, Marie-Annick Buendia, Yu Wei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2860980?pdf=render

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http://europepmc.org/articles/PMC2860980?pdf=render

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