A Replicating Single-Cycle Adenovirus Vaccine Effective against <i>Clostridium difficile</i>

A Replicating Single-Cycle Adenovirus Vaccine Effective against <i>Clostridium difficile</i>

<i>Clostridium difficile</i> causes nearly 500,000 infections and nearly 30,000 deaths each year in the U.S., which is estimated to cost $4.8 billion. <i>C. difficile</i> infection (CDI) arises from bacteria colonizing the large intestine and releasing two toxins, toxin A (Tc...

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Bibliographic Details
Main Authors: William E. Matchett, Stephanie Anguiano-Zarate, Goda Baddage Rakitha Malewana, Haley Mudrick, Melissa Weldy, Clayton Evert, Alexander Khoruts, Michael Sadowsky, Michael A. Barry
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Vaccines
Subjects:
Clostridium difficile
adenovirus
single-cycle
vaccine
animal models
Online Access:https://www.mdpi.com/2076-393X/8/3/470

Internet

https://www.mdpi.com/2076-393X/8/3/470

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