Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma

Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma

Abstract Background Cancer cells prefer utilizing aerobic glycolysis in order to exacerbate tumor mass and maintain un-regulated proliferative rates. As a key glycolytic activator, phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) has been implicated in multiple tumor type progression. H...

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Bibliographic Details
Main Authors: Jun Li, Shiqiang Zhang, Dingzhun Liao, Qian Zhang, Chujie Chen, Xiangwei Yang, Donggen Jiang, Jun Pang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Cancer
Subjects:
Renal cell carcinoma
PFKFB3
Glycolysis
Proliferation
G1/S transition
Online Access:https://doi.org/10.1186/s12885-022-09183-2

Internet

https://doi.org/10.1186/s12885-022-09183-2

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