Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures

Single‐Cell and Spatial Transcriptomics Decodes Wharton's Jelly‐Derived Mesenchymal Stem Cells Heterogeneity and a Subpopulation with Wound Repair Signatures

Abstract The highly heterogeneous characteristics of Wharton's jelly mesenchymal stem cells (WJ‐MSCs) may be responsible for the poor clinical outcomes and poor reproducibility of treatments based on WJ‐MSCs. Exploration of WJ‐MSC heterogeneity with multimodal single‐cell technologies will aid...

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Bibliographic Details
Main Authors: Penghong Chen, Shijie Tang, Ming Li, Dezhi Wang, Caixiang Chen, Yiqun Qiu, Zhuoqun Fang, Haoruo Zhang, Hangqi Gao, Haiyan Weng, Kailun Hu, Jian Lin, Qingxia Lin, Yi Tan, Shirong Li, Jinghua Chen, Liangwan Chen, Xiaosong Chen
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Advanced Science
Subjects:
heterogeneity
single‐cell RNA sequencing
spatial transcriptome
subpopulations
Wharton's jelly‐derived mesenchymal stem cells
Online Access:https://doi.org/10.1002/advs.202204786

Internet

https://doi.org/10.1002/advs.202204786

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