Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

The role of integrin-mediated adhesion during T cell progenitor homing to and differentiation within the thymus is ill-defined, mainly due to functional overlap. To circumvent compensation, we disrupted the hematopoietic integrin regulator kindlin-3 in mice and found a progressive thymus atrophy tha...

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Bibliographic Details
Main Authors: Federico Andrea Moretti, Sarah Klapproth, Raphael Ruppert, Andreas Margraf, Jasmin Weber, Robert Pick, Christoph Scheiermann, Markus Sperandio, Reinhard Fässler, Markus Moser
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
kindlin-3
integrin
T cell homing
thymus development
Online Access:https://elifesciences.org/articles/35816

Internet

https://elifesciences.org/articles/35816

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