Mechanism of HSP90 Inhibitor AUY-922 Reversing ALK Inhibitor Resistance in Human Neuroblastoma Cells

Mechanism of HSP90 Inhibitor AUY-922 Reversing ALK Inhibitor Resistance in Human Neuroblastoma Cells

Objective To investigate the mechanism of HSP90 inhibitor AUY-922 reversing the resistance of human neuroblastoma cells to the second generation ALK inhibitor TAE684. Methods The effect of AUY-922 on the proliferation of human neuroblastoma cells SH-SY5Y and KELLY carrying ALK F1174L gene was detect...

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Bibliographic Details
Main Authors: WANG Yueqin, FENG Luyao, TIAN Xin
Format: Article
Language:zho
Published: Magazine House of Cancer Research on Prevention and Treatment 2022-04-01
Series:Zhongliu Fangzhi Yanjiu
Subjects:
neuroblastoma
drug resistance
tae684
auy-922
cell cycle arrest
signal pathway
Online Access:http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.0949

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http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.0949

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