SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer

SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer

Abstract Lymph node (LN) metastasis is one of the predominant metastatic routes of non-small cell lung cancer (NSCLC) and is considered as a leading cause for the unsatisfactory prognosis of patients. Although lymphangiogenesis is well-recognized as a crucial process in mediating LN metastasis, the...

Full description

Bibliographic Details
Main Authors: Xiayao Diao, Chao Guo, Hanhao Zheng, Ke Zhao, Yuming Luo, Mingjie An, Yan Lin, Jiancheng Chen, Yuanlong Li, Yuting Li, Xuehan Gao, Jiaqi Zhang, Mengxin Zhou, Wenliang Bai, Lei Liu, Guige Wang, Lanjun Zhang, Xiaotian He, Rusi Zhang, Zhihua Li, Changhao Chen, Shanqing Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01685-0

Internet

https://doi.org/10.1038/s41392-023-01685-0

Similar Items