Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis

Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis

ObjectiveSeptic peritonitis is associated with significant morbidity and mortality. As a potential therapeutic agent in the treatment of sepsis, 2-O, 3-O desulfated heparin (ODSH) reduces histones and platelet factor 4 (PF4) in mouse sepsis models. This pilot clinical trial evaluated the safety and...

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Bibliographic Details
Main Authors: Katie D. Mauro, Michele P. Lambert, M. Anna Kowalska, Vincent J. Thawley, Mortimer Poncz, Cynthia M. Otto
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Veterinary Science
Subjects:
canine
heparin
platelet factor 4
sepsis
ODSH
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2022.862308/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2022.862308/full

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