Transcriptional Profiling of Human Endothelial Cells Unveils PIEZO1 and Mechanosensitive Gene Regulation by Prooxidant and Inflammatory Inputs

Transcriptional Profiling of Human Endothelial Cells Unveils PIEZO1 and Mechanosensitive Gene Regulation by Prooxidant and Inflammatory Inputs

PIEZO1 is a mechanosensitive cation channel implicated in shear stress-mediated endothelial-dependent vasorelaxation. Since altered shear stress patterns induce a pro-inflammatory endothelial environment, we analyzed transcriptional profiles of human endothelial cells to determine the effect of alte...

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Bibliographic Details
Main Authors: German A. Arenas, Jose G. Valenzuela, Estefanía Peñaloza, Adolfo A. Paz, Rodrigo Iturriaga, Claudia G. Saez, Bernardo J. Krause
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antioxidants
Subjects:
endothelial
mechanosensing
PIEZO1
NF-kappa B
prooxidants
disturbed blood flow
Online Access:https://www.mdpi.com/2076-3921/12/10/1874

Internet

https://www.mdpi.com/2076-3921/12/10/1874

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