Dopamine Transporter Knockout Rats Show Impaired Wellbeing in a Multimodal Severity Assessment Approach

Dopamine Transporter Knockout Rats Show Impaired Wellbeing in a Multimodal Severity Assessment Approach

In preclinical psychiatry research, animals are central to modeling and understanding biological mechanisms of behavior and psychiatric disorders. We here present the first multimodal severity assessment of a genetically modified rat strain used in psychiatric research, lacking the dopamine transpor...

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Bibliographic Details
Main Authors: Anne Stephanie Mallien, Laura Becker, Natascha Pfeiffer, Federica Terraneo, Melissa Hahn, Anthonieke Middelman, Rupert Palme, Kerstin Camile Creutzberg, Veronica Begni, Marco Andrea Riva, Damiana Leo, Heidrun Potschka, Fabio Fumagalli, Judith R. Homberg, Peter Gass
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
rat model
dopamine
psychiatry
animal welfare
severity assessment
behavior
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.924603/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2022.924603/full

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