Mitomycin‐C treatment during differentiation of induced pluripotent stem cell‐derived dopamine neurons reduces proliferation without compromising survival or function in vivo

Mitomycin‐C treatment during differentiation of induced pluripotent stem cell‐derived dopamine neurons reduces proliferation without compromising survival or function in vivo

Abstract Nongenetic methodologies to reduce undesirable proliferation would be valuable when generating dopamine neurons from stem cells for transplantation in Parkinson's disease (PD). To this end, we modified an established method for controlled differentiation of human induced pluripotent st...

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Bibliographic Details
Main Authors: Benjamin M. Hiller, David J. Marmion, Rachel M. Gross, Cayla A. Thompson, Carrie A. Chavez, Patrik Brundin, Dustin R. Wakeman, Christopher W. McMahon, Jeffrey H. Kordower
Format: Article
Language:English
Published: Oxford University Press 2021-02-01
Series:Stem Cells Translational Medicine
Subjects:
cell transplantation
immune‐deficient models
induced pluripotent stem cells
Parkinson's disease
Online Access:https://doi.org/10.1002/sctm.20-0014

Internet

https://doi.org/10.1002/sctm.20-0014

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