Hepatoprotective Effects of a Natural Flavanol 3,3′-Diindolylmethane against CCl<sub>4</sub>-Induced Chronic Liver Injury in Mice and TGFβ1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade

Hepatoprotective Effects of a Natural Flavanol 3,3′-Diindolylmethane against CCl<sub>4</sub>-Induced Chronic Liver Injury in Mice and TGFβ1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade

Hepatic fibrosis is a form of irregular wound-healing response with acute and chronic injury triggered by the deposition of excessive extracellular matrix. Epithelial–mesenchymal transition (EMT) is a dynamic process that plays a crucial role in the fibrogenic response and pathogenesis of liver fibr...

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Bibliographic Details
Main Authors: Suvesh Munakarmi, Yamuna Gurau, Juna Shrestha, Prabodh Risal, Ho Sung Park, Hyun Beak Shin, Yeon Jun Jeong
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
DIM
CCl<sub>4</sub>
TGFβ1
EMT
liver fibrosis
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/23/19/11407

Internet

https://www.mdpi.com/1422-0067/23/19/11407

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