NF-κB and pSTAT3 synergistically drive G6PD overexpression and facilitate sensitivity to G6PD inhibition in ccRCC

NF-κB and pSTAT3 synergistically drive G6PD overexpression and facilitate sensitivity to G6PD inhibition in ccRCC

Abstract Background Glucose 6-phosphate dehydrogenase (G6PD) serves key roles in cancer cell metabolic reprogramming, and has been reported to be involved in certain carcinogenesis. Previous results from our laboratory demonstrated that overexpressed G6PD was a potential prognostic biomarker in clea...

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Bibliographic Details
Main Authors: Qiao Zhang, Zhe Yang, Yueli Ni, Honggang Bai, Qiaoqiao Han, Zihan Yi, Xiaojia Yi, Yannick Luther Agbana, Yingmin Kuang, Yuechun Zhu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cancer Cell International
Subjects:
G6PD
ccRCC
ROS
NF-κB
pSTAT3
Proliferation inhibition
Online Access:http://link.springer.com/article/10.1186/s12935-020-01576-2

Internet

http://link.springer.com/article/10.1186/s12935-020-01576-2

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