Exercise Enhanced Cardiac Function in Mice With Radiation-Induced Heart Disease via the FNDC5/Irisin-Dependent Mitochondrial Turnover Pathway

Exercise Enhanced Cardiac Function in Mice With Radiation-Induced Heart Disease via the FNDC5/Irisin-Dependent Mitochondrial Turnover Pathway

Background: Despite the development of radiation therapy (RT) techniques, concern regarding the serious and irreversible heart injury induced by RT has grown due to the lack of early intervention measures. Although exercise can act as an effective and economic nonpharmacologic strategy to combat fat...

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Bibliographic Details
Main Authors: Wuyang He, Yinghong Tang, Chunqiu Li, Xiaoyue Zhang, Shunping Huang, Benxu Tan, Zhenzhou Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Physiology
Subjects:
FNDC5
irisin
radiation therapy
heart
aerobic exercise
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.739485/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.739485/full

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