Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models

Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models

Abstract Background Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It’s capacity of passing through the blood brain barrier makes is an attractive nove...

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Bibliographic Details
Main Authors: Huiyuan Zhang, Yuchen Du, Lin Qi, Sophie Xiao, Frank K. Braun, Mari Kogiso, Yulun Huang, Frank Huang, Aalaa Abdallah, Milagros Suarez, Sekar Karthick, Nabil M. Ahmed, Vita S. Salsman, Patricia A. Baxter, Jack M. Su, Daniel J. Brat, Paul L. Hellenbeck, Wan-Yee Teo, Akash J. Patel, Xiao-Nan Li
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Translational Medicine
Subjects:
Patient-derived orthotopic xenograft
Glioblastoma
Oncolytic virus
SVV-001
Therapeutic efficacy
Online Access:https://doi.org/10.1186/s12967-023-04237-w

Internet

https://doi.org/10.1186/s12967-023-04237-w

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