The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors.

The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors.

The mdx mouse is a good genetic and molecular murine model for Duchenne Muscular Dystrophy (DMD), a progressive and devastating muscle disease. However, this model is inappropriate for testing new therapies due to its mild phenotype. Here, we transferred the mdx mutation to the 129/Sv strain with th...

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Bibliographic Details
Main Authors: Priscila Clara Calyjur, Camila de Freitas Almeida, Danielle Ayub-Guerrieri, Antonio Fernando Ribeiro, Stephanie de Alcântara Fernandes, Renata Ishiba, Andre Luis Fernandes Dos Santos, Paula Onofre-Oliveira, Mariz Vainzof
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4783004?pdf=render

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http://europepmc.org/articles/PMC4783004?pdf=render

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