MCL-1 Inhibition by Selective BH3 Mimetics Disrupts Mitochondrial Dynamics Causing Loss of Viability and Functionality of Human Cardiomyocytes

MCL-1 Inhibition by Selective BH3 Mimetics Disrupts Mitochondrial Dynamics Causing Loss of Viability and Functionality of Human Cardiomyocytes

Summary: MCL-1 is a well-characterized inhibitor of cell death that has also been shown to be a regulator of mitochondrial dynamics in human pluripotent stem cells. We used cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) to uncover whether MCL-1 is crucial for cardiac fu...

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Bibliographic Details
Main Authors: Megan L. Rasmussen, Nilay Taneja, Abigail C. Neininger, Lili Wang, Gabriella L. Robertson, Stellan N. Riffle, Linzheng Shi, Bjorn C. Knollmann, Dylan T. Burnette, Vivian Gama
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220301991

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http://www.sciencedirect.com/science/article/pii/S2589004220301991

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