EpoR Activation Stimulates Erythroid Precursor Proliferation by Inducing Phosphorylation of Tyrosine-88 of the CDK-Inhibitor p27<sup>Kip1</sup>

EpoR Activation Stimulates Erythroid Precursor Proliferation by Inducing Phosphorylation of Tyrosine-88 of the CDK-Inhibitor p27<sup>Kip1</sup>

Erythrocyte biogenesis needs to be tightly regulated to secure oxygen transport and control plasma viscosity. The cytokine erythropoietin (Epo) governs erythropoiesis by promoting cell proliferation, differentiation, and survival of erythroid precursor cells. Erythroid differentiation is associated...

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Bibliographic Details
Main Authors: Fragka Pegka, Nathalie Ben-Califa, Drorit Neumann, Heidelinde Jäkel, Ludger Hengst
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
p27
EpoR
erythropoiesis
tyrosine phosphorylation
cell cycle
Online Access:https://www.mdpi.com/2073-4409/12/13/1704

Internet

https://www.mdpi.com/2073-4409/12/13/1704

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