Identifying Small Molecule-miRNA Associations Based on Credible Negative Sample Selection and Random Walk

Identifying Small Molecule-miRNA Associations Based on Credible Negative Sample Selection and Random Walk

Recently, many studies have demonstrated that microRNAs (miRNAs) are new small molecule drug targets. Identifying small molecule-miRNA associations (SMiRs) plays an important role in finding new clues for various human disease therapy. Wet experiments can discover credible SMiR associations; however...

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Bibliographic Details
Main Authors: Fuxing Liu, Lihong Peng, Geng Tian, Jialiang Yang, Hui Chen, Qi Hu, Xiaojun Liu, Liqian Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
SMiR associations
random walk
negative sample selection
triple-layer heterogeneous network
drug repositioning
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00131/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00131/full

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