Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

Drugs such as gemcitabine that increase replication stress are effective chemotherapeutics in a range of cancer settings. These drugs effectively block replication and promote DNA damage, triggering a cell cycle checkpoint response through the ATR–CHK1 pathway. Inhibiting this signalling pathway sen...

Full description

Bibliographic Details
Main Authors: Zay Yar Oo, Martina Proctor, Alexander J. Stevenson, Deborah Nazareth, Madushan Fernando, Sheena M. Daignault, Catherine Lanagan, Sebastian Walpole, Vanessa Bonazzi, Dubravka Škalamera, Cameron Snell, Nikolas K. Haass, Jill E. Larsen, Brian Gabrielli
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Molecular Oncology
Subjects:
CHK1 inhibitor
hydroxyurea
macrophage infiltration
replication stress
Online Access:https://doi.org/10.1002/1878-0261.12497

Internet

https://doi.org/10.1002/1878-0261.12497

Similar Items