The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells

The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells

Abstract Background Many cancers evade immune surveillance by overexpressing PD-L1. PD-L1 interacted with its receptor PD-1, resulting in reduction of T cell proliferation and activation and thereafter cancer cell death mediated by T-lymphocyte. Understanding the mechanisms that regulate PD-L1 was o...

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Bibliographic Details
Main Authors: Yu Wang, Qingguo Sun, Ning Mu, Xiaoyang Sun, Yingying Wang, Songqing Fan, Ling Su, Xiangguo Liu
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cell Communication and Signaling
Subjects:
PD-L1
USP22
CSN5
Deubiquitination
Immune checkpoint blockade therapy
Online Access:http://link.springer.com/article/10.1186/s12964-020-00612-y

Internet

http://link.springer.com/article/10.1186/s12964-020-00612-y

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