Genetic Risk Assessment of Degenerative Eye Disease (GRADE): study protocol of a prospective assessment of polygenic risk scores to predict diagnosis of glaucoma and age-related macular degeneration

Genetic Risk Assessment of Degenerative Eye Disease (GRADE): study protocol of a prospective assessment of polygenic risk scores to predict diagnosis of glaucoma and age-related macular degeneration

Abstract Background Glaucoma and age-related macular degeneration (AMD) account for a substantial portion of global blindness. Both conditions are highly heritable, with recognised monogenic and polygenic inheritance patterns. Current screening guidelines lack decisive recommendations. Polygenic ris...

Full description

Bibliographic Details
Main Authors: Georgina L Hollitt, Ayub Qassim, Daniel Thomson, Joshua M Schmidt, Thi Thi Nguyen, John Landers, Stuart MacGregor, Owen M Siggs, Emmanuelle Souzeau, Jamie E Craig
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Ophthalmology
Subjects:
Glaucoma
Polygenic risk score
Genetic testing
Macular degeneration
POAG
AMD
Online Access:https://doi.org/10.1186/s12886-023-03143-5

Internet

https://doi.org/10.1186/s12886-023-03143-5

Similar Items