Approaches towards Structures of Y Receptors, Examples of Human G-Protein Coupled Receptors, by Solution NMR

Despite recent advances no solution structure for a true G-protein coupled receptor (GPCR) is available today due to biochemical and spectroscopic problems. Herein we review our attempts to obtain assignments of GPCRs based on fragments comprising 2-3 transmembrane helices. The fragments a...

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Bibliographic Details
Main Authors: Reto Walser, Oliver Zerbe
Format: Article
Language:deu
Published: Swiss Chemical Society 2012-10-01
Series:CHIMIA
Subjects:
Online Access:https://www.chimia.ch/chimia/article/view/5287