Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity

Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity

GrB/scFvMEL, a fusion protein composed of human granzyme B (GrB) and the single-chain antibody scFvMEL, targets melanoma gp240 antigen and exerts impressive cytotoxic effects by inducing apoptosis. We evaluated the effects of GrB/scFvMEL on chemotherapy, radiation therapy, metastasis in vitro, and t...

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Bibliographic Details
Main Authors: Yuying Liu, Weihe Zhang, Ting Niu, Lawrence H. Cheung, Anupama Munshi, Raymond E. Meyn, Jr., Michael G. Rosenblum
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Granzyme B
single-chain Fv antibody
immunotoxin
apoptosis
melanoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800217

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http://www.sciencedirect.com/science/article/pii/S1476558606800217

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