Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity
GrB/scFvMEL, a fusion protein composed of human granzyme B (GrB) and the single-chain antibody scFvMEL, targets melanoma gp240 antigen and exerts impressive cytotoxic effects by inducing apoptosis. We evaluated the effects of GrB/scFvMEL on chemotherapy, radiation therapy, metastasis in vitro, and t...
Main Authors: | Yuying Liu, Weihe Zhang, Ting Niu, Lawrence H. Cheung, Anupama Munshi, Raymond E. Meyn, Jr., Michael G. Rosenblum |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2006-02-01
|
Series: | Neoplasia: An International Journal for Oncology Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558606800217 |
Similar Items
-
Soluble Cytoplasmic Expression and Purification of Immunotoxin HER2(scFv)-PE24B as a Maltose Binding Protein Fusion
by: Sangsu Park, et al.
Published: (2021-06-01) -
Human Cytolytic Fusion Proteins: Modified Versions of Human Granzyme B and Angiogenin Have the Potential to Replace Bacterial Toxins in Targeted Therapies against CD64+ Diseases
by: Nina Berges, et al.
Published: (2014-02-01) -
Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology
by: Patricia Guerrero-Ochoa, et al.
Published: (2020-08-01) -
<i>FvMYB79</i> Positively Regulates Strawberry Fruit Softening via Transcriptional Activation of <i>FvPME38</i>
by: Jianfa Cai, et al.
Published: (2021-12-01) -
Screening Antibody Libraries with Colony Assay Using scFv-Alkaline Phosphatase Fusion Proteins
by: Yoshiro Hanyu, et al.
Published: (2020-06-01)