An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities
Viral infectious diseases pose a great challenge to human health around the world. Type I interferons (IFN-Is) function as the first line of host defense and thus play critical roles during virus infection by mediating the transcriptional induction of hundreds of genes. Nevertheless, overactive cyto...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.742542/full |
| _version_ | 1818838278653083648 |
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| author | Guanghui Qian Liyan Zhu Gen Li Ying Liu Zimu Zhang Jian Pan Haitao Lv |
| author_facet | Guanghui Qian Liyan Zhu Gen Li Ying Liu Zimu Zhang Jian Pan Haitao Lv |
| author_sort | Guanghui Qian |
| collection | DOAJ |
| description | Viral infectious diseases pose a great challenge to human health around the world. Type I interferons (IFN-Is) function as the first line of host defense and thus play critical roles during virus infection by mediating the transcriptional induction of hundreds of genes. Nevertheless, overactive cytokine immune responses also cause autoimmune diseases, and thus, tight regulation of the innate immune response is needed to achieve viral clearance without causing excessive immune responses. Emerging studies have recently uncovered that the ubiquitin system, particularly deubiquitinating enzymes (DUBs), plays a critical role in regulating innate immune responses. In this review, we highlight recent advances on the diverse mechanisms of human DUBs implicated in IFN-I signaling. These DUBs function dynamically to calibrate host defenses against various virus infections by targeting hub proteins in the IFN-I signaling transduction pathway. We also present a future perspective on the roles of DUB-substrate interaction networks in innate antiviral activities, discuss the promises and challenges of DUB-based drug development, and identify the open questions that remain to be clarified. Our review provides a comprehensive description of DUBs, particularly their differential mechanisms that have evolved in the host to regulate IFN-I-signaling-mediated antiviral responses. |
| first_indexed | 2024-12-19T03:35:52Z |
| format | Article |
| id | doaj.art-f041c91a33974640bfc5283bfa740969 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T03:35:52Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f041c91a33974640bfc5283bfa7409692022-12-21T20:37:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-10-011210.3389/fimmu.2021.742542742542An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral ActivitiesGuanghui Qian0Liyan Zhu1Gen Li2Ying Liu3Zimu Zhang4Jian Pan5Haitao Lv6Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Experimental Center, Medical College of Soochow University, Suzhou, ChinaInstitute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaInstitute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaInstitute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaInstitute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaInstitute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaViral infectious diseases pose a great challenge to human health around the world. Type I interferons (IFN-Is) function as the first line of host defense and thus play critical roles during virus infection by mediating the transcriptional induction of hundreds of genes. Nevertheless, overactive cytokine immune responses also cause autoimmune diseases, and thus, tight regulation of the innate immune response is needed to achieve viral clearance without causing excessive immune responses. Emerging studies have recently uncovered that the ubiquitin system, particularly deubiquitinating enzymes (DUBs), plays a critical role in regulating innate immune responses. In this review, we highlight recent advances on the diverse mechanisms of human DUBs implicated in IFN-I signaling. These DUBs function dynamically to calibrate host defenses against various virus infections by targeting hub proteins in the IFN-I signaling transduction pathway. We also present a future perspective on the roles of DUB-substrate interaction networks in innate antiviral activities, discuss the promises and challenges of DUB-based drug development, and identify the open questions that remain to be clarified. Our review provides a comprehensive description of DUBs, particularly their differential mechanisms that have evolved in the host to regulate IFN-I-signaling-mediated antiviral responses.https://www.frontiersin.org/articles/10.3389/fimmu.2021.742542/fulldeubiquitinating enzymestype I IFN signalingubiquitinvirus infectioninnate immunity |
| spellingShingle | Guanghui Qian Liyan Zhu Gen Li Ying Liu Zimu Zhang Jian Pan Haitao Lv An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities Frontiers in Immunology deubiquitinating enzymes type I IFN signaling ubiquitin virus infection innate immunity |
| title | An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities |
| title_full | An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities |
| title_fullStr | An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities |
| title_full_unstemmed | An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities |
| title_short | An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities |
| title_sort | integrated view of deubiquitinating enzymes involved in type i interferon signaling host defense and antiviral activities |
| topic | deubiquitinating enzymes type I IFN signaling ubiquitin virus infection innate immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.742542/full |
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