Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene[S]

Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene[S]

Sphingomyelin synthase (SMS) produces sphingomyelin while consuming ceramide (a negative regulator of cell proliferation) and forming diacylglycerol (DAG) (a mitogenic factor). Therefore, enhanced SMS activity could favor cell proliferation. To examine if dysregulated SMS contributes to leukemogenes...

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Bibliographic Details
Main Authors: Tara Ann Burns, Marimuthu Subathra, Paola Signorelli, Young Choi, Xiaofeng Yang, Yong Wang, Maristella Villani, Kapil Bhalla, Daohong Zhou, Chiara Luberto
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Journal of Lipid Research
Subjects:
ceramide
diacylglycerol
imatinib mesylate
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520419431

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http://www.sciencedirect.com/science/article/pii/S0022227520419431

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