The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage

The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage

Alternate splicing of mRNA precursors has been linked to tumor development. Here the authors reveal a role of the E3 ligase RNF113A in spliceosome regulation affecting cell survival upon DNA damage.

Bibliographic Details
Main Authors: Kateryna Shostak, Zheshen Jiang, Benoit Charloteaux, Alice Mayer, Yvette Habraken, Lars Tharun, Sebastian Klein, Xinyi Xu, Hong Quan Duong, Andrii Vislovukh, Pierre Close, Alexandra Florin, Florian Rambow, Jean-Christophe Marine, Reinhard Büttner, Alain Chariot
Format: Article
Language:English
Published: Nature Portfolio 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15003-7

Internet

https://doi.org/10.1038/s41467-020-15003-7

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