Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells

Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells

ABSTRACT Chronic hepatitis C virus (HCV) infection induces liver inflammation that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Inflammation is the outcome of the action of proinflammatory cytokines and chemokines, including interleukin-1 beta (IL-1β) and tumor necrosis facto...

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Bibliographic Details
Main Authors: Akshaya Ramachandran, Binod Kumar, Gulam Waris, David Everly
Format: Article
Language:English
Published: American Society for Microbiology 2021-09-01
Series:Microbiology Spectrum
Subjects:
hepatitis C virus
NLRP3
IL-1β
UCHL5
deubiquitination
inflammation
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00755-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.00755-21

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