A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease

A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease

Abstract Background Perianal fistulas (PF) affect one-third patients with Crohn’s disease (CD) with limited therapeutic options. There is dearth of literature on safety and efficacy of bone marrow-derived mesenchymal stromal cells (BMSCs) in this population. Methods An open-label, phase I/II, single...

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Bibliographic Details
Main Authors: Shekhar Swaroop, Sudheer Kumar Vuyyuru, Bhaskar Kante, Peeyush Kumar, Sandeep Kumar Mundhra, Umang Arora, Ankur Goyal, Devasenathipathy Kandasamy, Raju Sharma, Kavirajan Kabilan, Saurabh Kedia, Nihar Ranjan Dash, Vineet Ahuja
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Stem Cell Research & Therapy
Subjects:
Perianal CD
Fistula
Stem cell
Online Access:https://doi.org/10.1186/s13287-024-03746-9

Internet

https://doi.org/10.1186/s13287-024-03746-9

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