Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening

Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening

The screening of chemical libraries based on cellular biosensors is a useful approach to identify new hits for novel therapeutic targets involved in rare genetic pathologies, such as <i>β</i>-thalassemia and sickle cell disease. In particular, pharmacologically mediated stimulation of hu...

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Bibliographic Details
Main Authors: Giulia Breveglieri, Salvatore Pacifico, Cristina Zuccato, Lucia Carmela Cosenza, Shaiq Sultan, Elisabetta D’Aversa, Roberto Gambari, Delia Preti, Claudio Trapella, Remo Guerrini, Monica Borgatti
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
hemoglobinopathies
<i>β</i>-thalassemia
sickle cell disease
fetal hemoglobin
chemical screening
compound library
Online Access:https://www.mdpi.com/1422-0067/21/19/7426

Internet

https://www.mdpi.com/1422-0067/21/19/7426

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