YAP promotes global mRNA translation to fuel oncogenic growth despite starvation
Abstract Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) play fundamental roles in stem/progenitor cell expansion during homeostasis, and their dysregulation often leads to tissue overgrowth. Here, we show that YAP activation is sufficient to overcome the r...
| Hoofdauteurs: | , , , , , , , , , , |
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| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
Nature Publishing Group
2024-10-01
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| Reeks: | Experimental and Molecular Medicine |
| Online toegang: | https://doi.org/10.1038/s12276-024-01316-w |