Site-Specific Conjugation for Fully Controlled Glycoconjugate Vaccine Preparation

Site-Specific Conjugation for Fully Controlled Glycoconjugate Vaccine Preparation

Glycoconjugate vaccines are formed by covalently link a carbohydrate antigen to a carrier protein whose role is to achieve a long lasting immune response directed against the carbohydrate antigen. The nature of the sugar antigen, its length, its ratio per carrier protein and the conjugation chemistr...

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Bibliographic Details
Main Authors: Aline Pillot, Alain Defontaine, Amina Fateh, Annie Lambert, Maruthi Prasanna, Mathieu Fanuel, Muriel Pipelier, Noemi Csaba, Typhaine Violo, Emilie Camberlein, Cyrille Grandjean
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
glycoconjugate vaccine
cysteine mutagenesis
chemoselective ligation
protein conjugation
pneumococcal vaccine
thio/maleimide ligation
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00726/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00726/full

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