Salmonella and Caspase-1: a complex interplay of detection and evasion
Salmonellae are intracellular pathogens that replicate within epithelial cells and macrophages, and are a significant public health threat in both developed and developing countries. The innate immune system detects microbes through pattern recognition receptors, which are compartmentalized on the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00085/full |
| _version_ | 1819230984438022144 |
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| author | Edward A Miao Jayant V Rajan Jayant V Rajan |
| author_facet | Edward A Miao Jayant V Rajan Jayant V Rajan |
| author_sort | Edward A Miao |
| collection | DOAJ |
| description | Salmonellae are intracellular pathogens that replicate within epithelial cells and macrophages, and are a significant public health threat in both developed and developing countries. The innate immune system detects microbes through pattern recognition receptors, which are compartmentalized on the subcellular level to detect either extracellular (e.g. TLRs) or cytosolic (e.g. NLRs) perturbations. Salmonella infection is detected by the NLRC4 and NLRP3 inflammasomes, which activate Caspase-1, resulting in reduced bacterial burdens during infection. NLRC4 responds to the SPI1 type III secretion system via detection of inadvertently translocated flagellin and rod protein. The signals for NLRP3 detection during Salmonella infection remain undefined. Salmonella have evolved evasion strategies to attenuate Caspase-1 responses. We review recent findings describing the interplay between detection and evasion of S. typhimurium infection by the inflammasome. We discuss how the interplay between detection and evasion affects Caspase-1 effector functions mediated by IL-1β secretion, IL-18 secretion, and pyroptosis. |
| first_indexed | 2024-12-23T11:37:45Z |
| format | Article |
| id | doaj.art-f04fa74ba1344af7a816c93e3438bb5a |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-23T11:37:45Z |
| publishDate | 2011-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f04fa74ba1344af7a816c93e3438bb5a2022-12-21T17:48:35ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882011-04-01210.3389/fmicb.2011.0008510316Salmonella and Caspase-1: a complex interplay of detection and evasionEdward A Miao0Jayant V Rajan1Jayant V Rajan2Institute for Systems BiologyInstitute for Systems BiologyUniversity of WashingtonSalmonellae are intracellular pathogens that replicate within epithelial cells and macrophages, and are a significant public health threat in both developed and developing countries. The innate immune system detects microbes through pattern recognition receptors, which are compartmentalized on the subcellular level to detect either extracellular (e.g. TLRs) or cytosolic (e.g. NLRs) perturbations. Salmonella infection is detected by the NLRC4 and NLRP3 inflammasomes, which activate Caspase-1, resulting in reduced bacterial burdens during infection. NLRC4 responds to the SPI1 type III secretion system via detection of inadvertently translocated flagellin and rod protein. The signals for NLRP3 detection during Salmonella infection remain undefined. Salmonella have evolved evasion strategies to attenuate Caspase-1 responses. We review recent findings describing the interplay between detection and evasion of S. typhimurium infection by the inflammasome. We discuss how the interplay between detection and evasion affects Caspase-1 effector functions mediated by IL-1β secretion, IL-18 secretion, and pyroptosis.http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00085/fullSalmonellaInflammasomecaspase-1IL-1bpyroptosis |
| spellingShingle | Edward A Miao Jayant V Rajan Jayant V Rajan Salmonella and Caspase-1: a complex interplay of detection and evasion Frontiers in Cellular and Infection Microbiology Salmonella Inflammasome caspase-1 IL-1b pyroptosis |
| title | Salmonella and Caspase-1: a complex interplay of detection and evasion |
| title_full | Salmonella and Caspase-1: a complex interplay of detection and evasion |
| title_fullStr | Salmonella and Caspase-1: a complex interplay of detection and evasion |
| title_full_unstemmed | Salmonella and Caspase-1: a complex interplay of detection and evasion |
| title_short | Salmonella and Caspase-1: a complex interplay of detection and evasion |
| title_sort | salmonella and caspase 1 a complex interplay of detection and evasion |
| topic | Salmonella Inflammasome caspase-1 IL-1b pyroptosis |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00085/full |
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