Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory

Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory

Abstract Metastasis arises from disseminated tumour cells (DTCs) that are characterized by intrinsic phenotypic plasticity and the capability of seeding to secondary organs. DTCs can remain latent for years before giving rise to symptomatic overt metastasis. In this context, DTCs fluctuate between a...

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Bibliographic Details
Main Authors: Daniela Michelatti, Sven Beyes, Chiara Bernardis, Maria Luce Negri, Leonardo Morelli, Naiara Garcia Bediaga, Vittoria Poli, Luca Fagnocchi, Sara Lago, Sarah D’Annunzio, Nicole Cona, Ilaria Gaspardo, Aurora Bianchi, Jovana Jovetic, Matteo Gianesello, Alice Turdo, Caterina D’Accardo, Miriam Gaggianesi, Martina Dori, Mattia Forcato, Giuliano Crispatzu, Alvaro Rada-Iglesias, Maria Soledad Sosa, H. T. Marc Timmers, Silvio Bicciato, Matilde Todaro, Luca Tiberi, Alessio Zippo
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46524-0

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https://doi.org/10.1038/s41467-024-46524-0

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