Molecular function limits divergent protein evolution on planetary timescales

Functional conservation is known to constrain protein evolution. Nevertheless, the long-term divergence patterns of proteins maintaining the same molecular function and the possible limits of this divergence have not been explored in detail. We investigate these fundamental questions by characterizi...

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Bibliographic Details
Main Authors: Mariam M Konaté, Germán Plata, Jimin Park, Dinara R Usmanova, Harris Wang, Dennis Vitkup
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/39705