Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells

Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells

The study of congenital virus infections in humans requires suitable ex vivo platforms for the species-specific events during embryonal development. A prominent example for these infections is rubella virus (RV) which most commonly leads to defects in ear, heart, and eye development. We applied tera...

Full description

Bibliographic Details
Main Authors: Nicole C. Bilz, Edith Willscher, Hans Binder, Janik Böhnke, Megan L. Stanifer, Denise Hübner, Steeve Boulant, Uwe G. Liebert, Claudia Claus
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
ectoderm
mesoderm
human development
embryogenesis
interferon response
interferon-induced genes
self-organizing map (SOM) data portrayal
epigenetic signature
embryoid body
TGF-β and Wnt/β-catenin pathway
Online Access:https://www.mdpi.com/2073-4409/8/8/870

Internet

https://www.mdpi.com/2073-4409/8/8/870

Similar Items