Integration of Adverse Outcome Pathways, Causal Networks and ‘Omics to Support Chemical Hazard Assessment

Several approaches have been used in an attempt to simplify and codify the events that lead to adverse effects of chemicals including systems biology, ‘omics, in vitro assays and frameworks such as the Adverse Outcome Pathway (AOP). However, these approaches are generally not integrated despite thei...

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Bibliographic Details
Main Authors: Edward J. Perkins, E. Alice Woolard, Natàlia Garcia-Reyero
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Toxicology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.786057/full