A novel Glycyrrhiza glabra extract liquiritin targeting NFATc1 activity and ROS levels to counteract ovariectomy-induced osteoporosis and bone loss in murine model

A novel Glycyrrhiza glabra extract liquiritin targeting NFATc1 activity and ROS levels to counteract ovariectomy-induced osteoporosis and bone loss in murine model

Osteoporosis, a prevalent osteolytic condition worldwide, necessitates effective strategies to inhibit excessive bone resorption by curbing osteoclast hyperactivation. Liquiritin (LIQ), an flavanone derivative employed in acute lung injury and rheumatoid arthritis treatment, possesses an unclear rol...

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Bibliographic Details
Main Authors: Guoju Hong, Lin Zhou, Guanqiang Zheng, Xiaoxia Zheng, Zhenqiu Chen, Wei He, Qiushi Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
liquiritin
osteoclast
NFAcT1
RANKL
osteoporosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1287827/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1287827/full

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