Blockade of the BLT1-LTB4 axis does not affect mast cell migration towards advanced atherosclerotic lesions in LDLr−/− mice

Blockade of the BLT1-LTB4 axis does not affect mast cell migration towards advanced atherosclerotic lesions in LDLr−/− mice

Abstract Mast cells have been associated with the progression and destabilization of advanced atherosclerotic plaques. Reducing intraplaque mast cell accumulation upon atherosclerosis progression could be a potent therapeutic strategy to limit plaque destabilization. Leukotriene B4 (LTB4) has been r...

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Bibliographic Details
Main Authors: Marie A. C. Depuydt, Femke D. Vlaswinkel, Esmeralda Hemme, Lucie Delfos, Mireia N. A. Bernabé Kleijn, Peter J. van Santbrink, Amanda C. Foks, Bram Slütter, Johan Kuiper, Ilze Bot
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23162-4

Internet

https://doi.org/10.1038/s41598-022-23162-4

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