Functional Consequences of Mutations in Myeloproliferative Neoplasms

Driver mutations occur in Janus kinase 2 (JAK2), thrombopoietin receptor (MPL), and calreticulin (CALR) in BCR-ABL1 negative myeloproliferative neoplasms (MPNs). From mutations leading to one amino acid substitution in JAK2 or MPL, to frameshift mutations in CALR resulting in a protein with a differ...

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Bibliographic Details
Main Authors: Stefan N. Constantinescu, William Vainchenker, Gabriel Levy, Nicolas Papadopoulos
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000578