PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells

PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells

This study aims to design a pH-responsive dual-loaded nanosystem based on PEGylated chitosan nanoparticles loaded with ascorbic acid (AA) and oxaliplatin (OX) for the effective treatment of breast cancer. In this regard, non-PEGylated and PEGylated chitosan nanoparticles (CS NPs) loaded with either...

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Bibliographic Details
Main Authors: Sherif Ashraf Fahmy, Asmaa Ramzy, Asmaa A. Mandour, Soad Nasr, Anwar Abdelnaser, Udo Bakowsky, Hassan Mohamed El-Said Azzazy
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
chitosan nanoparticles
PEG
oxaliplatin
ascorbic acid (vitamin C)
ionic gelation method
breast cancer
Online Access:https://www.mdpi.com/1999-4923/14/2/407

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https://www.mdpi.com/1999-4923/14/2/407

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